Research subject

Our team aims at understanding the biological and computational principles underlying motor control and procedural learning both in normal and pathological conditions (i.e. Parkinson’s disease, dystonia, or epilepsy).

We study the properties of neural networks in various brain circuits linking areas of the cortex, to the basal ganglia and the cerebellum across a wide range of species (including newts, songbirds, rodents and primates). The ambitious nature of our research, that is to understand the complex dynamics of neuronal networks, requires the constant development of innovative methods, both experimental: large-scale in vivo electrophysiological/optical recordings coupled with circuit-specific perturbations (such as opto/pharmacogenetics and closed-loop behavioural manipulations), and theoretical: analysis and simulations of biologically realistic models.

Our team also relies on strong interactions between scientists performing fundamental research and clinicians working at the hospital with patients with the ultimate goal to push forward the translational impact of our discoveries.

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Latest publications

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Criteria : Author : "arthur,leblois;nicolas,mallet,thomas,boreau;pierre,burbaud;marc,deffains;alexis,dubreuil", Publication type : "('ART')"
Number of occurrences founded : 73.

titre
Protocol for extracellular recordings in the external globus pallidus of the behaving/awake monkey
auteur
Shiran Katabi, Zvi Israel, Hagai Bergman, Marc Deffains
article
STAR Protocols, 2024, 5 (2), pp.103081. ⟨10.1016/j.xpro.2024.103081⟩
identifiant
hal-04671539
titre
Lessons from multitarget neurostimulation in isolated dystonia: Less is more?
auteur
Marie-Charlotte Cuartero, David Grabli, Emmanuel Flamand-Roze, Carine Karachi, Tiphaine Rouaud, Pascal Derkinderen, Philippe Damier, Sylvie Raoul, Paul Krack, Elena Moro, Valérie Fraix, Stéphan Chabardès, Pierre Burbaud, Dominique Guehl, Emmanuel Cuny, Serge Pinto, Marie Vidailhet
article
Brain Stimulation, 2024, 17 (1), pp.104-106. ⟨10.1016/j.brs.2023.12.012⟩
identifiant
hal-04416125
titre
Usefulness of thalamic beta activity for closed-loop therapy in essential tremor
auteur
Dominique Guehl, Etienne Guillaud, N. Langbour, Emilie Doat, N. Auzou, E. Courtin, O. Branchard, J. Engelhardt, A. Benazzouz, A. Eusebio, E. Cuny, Pierre Burbaud
article
Scientific Reports, 2023, 13 (1), ⟨10.1038/s41598-023-49511-5⟩
identifiant
hal-04409319
titre
A response to claims of emergent intelligence and sentience in a dish
auteur
Fuat Balci, Suliann Ben Hamed, Thomas Boraud, Sébastien Bouret, Thomas Brochier, Cédric Brun, Jeremiah Cohen, Etienne Coutureau, Marc Deffains, Valérie Doyère, Georgia Gregoriou, J. Alexander Heimel, Bjørg Elisabeth Kilavik, Daeyeol Lee, Eric Leuthardt, Zachary Mainen, Mackenzie Mathis, Ilya Monosov, Jérémie Naudé, Amy Orsborn, Camillo Padoa-Schioppa, Emmanuel Procyk, Bernardo Sabatini, Alireza Soltani, Jérôme Sallet, Carmen Sandi, Jeffrey Schall, Karel Svoboda, Charles R.E. Wilson, Jan Zimmermann
article
Neuron, 2023, 111 (5), pp.604-605. ⟨10.1016/j.neuron.2023.02.009⟩
identifiant
hal-04012408
titre
How does Tourette syndrome impact adolescents’ daily living? A text mining study
auteur
Cyril Atkinson-Clement, Marion Duflot, Eloise Lastennet, Leïla Patsalides, Emma Wasserman, Therese-Marie Sartoris, Clément Tarrano, Charlotte Rosso, Pierre Burbaud, Emmanuelle Deniau, Virginie Czernecki, Emmanuel Roze, Andreas Hartmann, Yulia Worbe
article
European Child and Adolescent Psychiatry, 2023, 32 (12), pp.2623-2635. ⟨10.1007/s00787-022-02116-1⟩
identifiant
hal-04351255