Pathophysiology of proteinopathies
DEHAY Benjamin (INSERM Research Director) PLANCHE Vincent (Physician/Researcher) MARTIN-NEGRIER Marie-Laure (Physician/Researcher) MEISSNER Wassilios (Researcher) AROTCARENA Marie-Laure (Engineer) BOUIT Lou (Engineer) CANRON Marie-Hélène (Engineer) MATHOUX Justine (Engineer) MAZZOCCO Claire (Engineer) THIOLAT Marie-Laure (Assistant-engineer) DARRICAU Morgane (Post-doctoral Researcher) ESTAUN-PANZANO Juan (PhD student) KINET Rémi (PhD student) LE QUANG Megane (PhD student) LOVISOTTO Anna (PhD Student ) TOUSSAINT Clara (PhD Student)
Research subject
Our research team aims to understand the molecular and cellular mechanisms responsible for the brain degeneration in proteinopathies and (ii) the subsequent symptoms in these same diseases. Three proteins receive our attention: alpha-synuclein, Tau and TDP-43.
Our research is developed around different axes:
- Biophysics of amyloid polymorphs.
This axis proposes to study the structure-activity relationship of amyloids using numerous biochemical and biophysical tools applied to synthetic assemblies and brain extracts from patients, but also based on in vitro models based on primary neuronal and glial cultures. These analytical and functional approaches aim at deciphering the cascade of events linking amyloid aggregation to neurodegeneration and at identifying molecular targets for the development of neuroprotective approaches.
- Modeling proteinopathies
This line of research, conducted in vivo, will allow us to study (i) the mechanistic of the induced degeneration and (ii) the pathophysiological consequences (behaviour, electrophysiology, neurochemistry, anatomo-pathology) through the administration of aggregated proteins in rodents and non-human primates. The specific role of the extra-cellular space in the propagation of aggregative information is particularly highlighted.
- Physiopathology of autophagic dysfunctions
These proteinopathies are all accompanied by autophagy dysfunctions (autophagic lysosomal pathway, macroautophagy, mitophagy, chaperone-mediated autophagy). Based on pathophysiological investigations, this axis aims to develop innovative therapeutic approaches (nanotechnology, gene therapy) for these different pathways in proteinopathies.
- Therapeutics for disease symptoms
Our history includes, in collaboration with the Centre Hospitalier Régional Universitaire de Bordeaux, a translational approach in the field of neurodegenerative diseases oriented towards disease management and medical applications. We aim to identify new therapeutic targets for specific symptoms through pathophysiological studies in experimental models and humans.
Dernières publications
Criteria : Author : "Bezard", Laboratoire(Affiliation) : "UMR5293", Publication type : "('ART')"
Number of occurrences founded : 208.
- titre
- A population of Insula neurons encodes for social preference only after acute social isolation in mice
- auteur
- Christelle Glangetas, Adriane Guillaumin, Elodie Ladevèze, Anaelle Braine, Manon Gauthier, Léa Bonamy, Evelyne Doudnikoff, Thibault Dhellemmes, Marc Landry, Erwan Bézard, Stephanie Caille, Anne Taupignon, Jérôme Baufreton, François Georges
- article
- Nature Communications, 2024, 15 (1), pp.7142. ⟨10.1038/s41467-024-51389-4⟩
- identifiant
- hal-04681539
- titre
- Nigral ATP13A2 depletion induces Parkinson’s disease-related neurodegeneration in a pilot study in non-human primates
- auteur
- Joanna Sikora, Sandra Dovero, Rémi Kinet, Marie-Laure Arotcarena, Sylvain Bohic, Erwan Bezard, Pierre-Olivier Fernagut, Benjamin Dehay
- article
- npj Parkinson's Disease, 2024, 10 (1), pp.141. ⟨10.1038/s41531-024-00757-4⟩
- identifiant
- inserm-04666309
- titre
- Nigral ATP13A2 depletion induces Parkinson’s disease-related neurodegeneration in a pilot study in non-human primates
- auteur
- Joanna Sikora, Sandra Dovero, Rémi Kinet, Marie-Laure Arotcarena, Sylvain Bohic, Erwan Bezard, Pierre-Olivier Fernagut, Benjamin Dehay
- article
- npj Parkinson's Disease, 2024, 10 (1), pp.141. ⟨10.1038/s41531-024-00757-4⟩
- identifiant
- hal-04727576
- titre
- Modeling Parkinson's Disease in Primates
- auteur
- Erwan Bezard, Margaux Teil, Marie-Laure Arotcarena, Gregory Porras, Qin Li, Benjamin Dehay
- article
- Cold Spring Harbor Perspectives in Medicine, 2024, pp.a041612. ⟨10.1101/cshperspect.a041612⟩
- identifiant
- inserm-04607791
- titre
- Une neuroprothèse spinale contre les déficits locomoteurs de la maladie de Parkinson
- auteur
- Erwan Bezard, Jocelyne Bloch, Grégoire Courtine
- article
- Médecine/Sciences, 2024, 40 (1), pp.104-106. ⟨10.1051/medsci/2023185⟩
- identifiant
- hal-04433409